Recent findings have also suggested that ER-β and ER-α have ligand-independent effects on motility and migration when expressed in MDA-MB-231 breast cancer cells [ 18].
Recent work confirmed the findings [8, 10, 11] that PTEN G129E, lacking PtdIns 3,4,5 P3 phosphatase activity, could inhibit cell motility as efficiently as the wild-type enzyme, when expressed through microinjection of expression constructs into PTEN null glioblastoma cells [5].
They found that only one LIM protein, JUB, was positively correlated with EMT progression in colorectal cancer cell lines, and when expressed ectopically, promoted motility, invasiveness, and EMT.
MenaINV, (originally termed Mena+++), expression confers a potent pro-metastatic phenotype when expressed in breast cancer cells by potentiating their chemotactic response to epidermal growth factor (EGF), thereby enhancing their ability to engage in efficient streaming motility via increasing their paracrine signaling with macrophages [ 3, 13, 14].
It confers a potent pro-invasion, pro-metastatic phenotype when expressed in breast cancer cells by potentiating their chemotactic invasion/migration response to EGF and by promoting discohesive cell motility [ 11, 17– 17].
When expressed, ELY16 is rich in tyrosine.
When expressed at the cell surface, RHAMM serves as a receptor for hyaluronic acid and has been implicated in both tumour cell motility and invasiveness (Hardwick et al, 1992).
When expressed at a level comparable to that in MCF10A parental cells, this shRNA-resistant LARP7 readily restored the loss of 7SK snRNA (Fig. 2G), reverted the morphology of the cells to the epithelial-like and mitigated the enhanced cell migration and motility, confirming that the increased EMT and cell migration are due to the loss of LARP7.
Use assertive statements when expressing yourself.
Stick with "a" when expressing indirect objects.
