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We already demonstrated that p27 is able to inhibit the motility of several human cancer cell lines, including HT-1080 fibrosarcellscells (Figure 6) and [19] and U87MG [data not shown and Ref 20] in transwell migration assays.
Since the process of myoblast chemotaxis is poorly understood and Ang II has been implicated in the motility of several cell types [19] [21], we assessed the role of Ang II in regulating myoblast chemotaxis using an assay commonly utilized to assess inflammatory cell migration [30].
Re-expression of PTEN in mammalian cells lacking the enzyme has been found to inhibit the motility of several lineages of such cells, including mouse embryo fibroblasts and tumor-derived cells of glial and prostate origin [8], [27], [28], although most of these studies have not addressed the mechanism of action of PTEN.
Both, 0.2 ng/ml exogenous TGF-β and CoCM, were capable of inducing scattering of MCF-7 and T47D cells (Fig. S3), indicating that low concentrations of TGF-β as found in CoCM can increase motility of several breast cancer cell lines.
To assess further the relationship between cadherin expression and neural tumour invasion, we measured N-cadherin expression, calcium-dependent cell adhesion and motility of several glioblastoma cell lines.
As MT1 promotes the motility of several cancer cell types on various matrices including collagen (Gingras et al, 2001; Rozanov et al, 2001; Takino et al, 2004), we evaluated this potential association within our panel of ovarian cancer cell lines.
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There have been several studies regarding HMGB1 stimulating the motility of various cell types such as fibroblasts, dendritic cells, macrophages, smooth muscle cells, and, most recently, neutrophils.
Amoeboid motility is one of several diverse modes adopted by disseminating tumour cells.
In accordance with its contribution to motility and invasion of several cancers (van Golen et al, 2000b; He et al, 2008), our data show that RhoC contributes to tumour progression by affecting invasion, anoikis resistance, tumour growth and angiogenesis in cervical carcinoma cell lines.
The peptide, BP-1, abrogates PlGF-driven cellular motility and several of the PlGF-mediated changes in intracellular signalling, and this may, in part, explain its anti-tumour activity.
Small intestine motility has been the focus of several HR electrical mapping studies in recent years, performed by Lammers et al. in SmoothMap [ 37, 38].
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