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We demonstrate that minor virulence features important for disease in mammals, such as extracellular enzymes and flagellum-based motility, have a key role in the replication and transmission of V. cholerae in its aqueous environment.
In addition to these 10 genes or operons, another 24 involved in motility have a putative MrpC binding site located between -400 and +100 relative to their predicted TCS (see Additional file 7, column D; Additional file 6, description and process) but either developmental regulation was missed in the microarray experiments or MrpC does not regulate these genes.
While our experimental procedures (ChIP-Seq) cannot determine if the observed Pol II is transcriptionally engaged [ 53], we find that genes likely to be associated with sperm motility have a Pol II signal around their TSS's as early as at 10dpp.
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We concluded, therefore, that motility has a major role in V. cholerae's interaction with A. castellanii.
We discover that in this scenario motility has a positive effect on invasion probability.
Cell motility has a key role in tumour cell invasion into the surrounding non-tumour tissues and is a major determinant of the aggressive nature of a tumour cell.
We therefore wondered whether motility would have a role in the escape of V. cholerae from the lysed CV and lysed cysts.
From those studies it has become evident that motility can have a profound impact on the colonization of surfaces [5] [9].
However, the effects of emotionally salient stimuli on gastrointestinal motility have scarcely been studied.
Spermatozoa with decreased motility have been reported in HBV-infected patients.
However, the underlying molecular mechanisms of how DLC1 suppresses cell motility have not been fully elucidated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com