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Indomethacin has been used at higher doses as a model of inflammatory bowel disease (IBD) [27], [28], and has been shown to compromise epithelial barrier integrity and function, induce motility changes, and promote small intestinal bacterial overgrowth and translocation [27], [29].
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Increasing evidence from breast and other cancers, however, suggests that a key feature of c-Src is to drive adhesive and motility changes crucial for invasion and metastasis [ 3, 9].
However, correlation between induction of pain and motility changes is poor.
Cellomics Cell Motility reagent kit (see Methods) was used to analyze and quantify cell motility changes.
In animal models as well as humans, drugs that interfere with NO, the primary inhibitory neurotransmitter in the esophagus, produce motility changes that mimic achalasia.
The utility of this approach is highlighted by analysis of heterogenous prostate cancer cell motility changes as a function of position in the stress landscape.
After this initial period of dispersal, sporozoite motility changes.
Our work demonstrates how directly altering mitochondrial turnover, dynamics, or motility changes the age profile of MitoTimer.
We did not observe any symptoms of gastric motility changes (vomiting) in any animal after general anaesthesia.
These data suggest that sporozoite motility changes over time such that after an initial phase of maximal dispersal, sporozoites move in more constrained circular paths.
It is therefore reasonable to assume that the motility changes seen in intestinal allergy will resemble those seen in other defensive states.
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