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The ability to assemble distinct and dynamic actin structures in the same cell is critical for the diverse role of actin in cell motility and morphogenesis [1].
Although stress fibers (bundles of actin filaments) play a central role in adhesion, motility, and morphogenesis of eukaryotic cells, the mechanism of how these and other contractile actomyosin structures are controlled and redistributed in the cell is not well understood.
HGF regulates cell growth, cell motility, and morphogenesis by activating a tyrosine signalling cascade [ 220].
Hepatocyte growth factor (HGF) is a mesenchymal-derived pleiotropic factor that regulates growth, motility, and morphogenesis of various cells (1).
HS/Hp interact with hepatocyte growth factor, which regulates cell growth, motility, and morphogenesis of epithelial or endothelial cells and stimulates epithelial repair and neovascularization [ 46, 53, 59].
Subsequently, a novel function for SLIT and ROBO in the inhibition of growth factor-mediated epithelial cell motility and morphogenesis has been disclosed.
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After binding to its cognate ligand-hepatocyte growth factor (HGF), activated c-Met transmits signals implicated in the cell proliferation, motility, survival, and morphogenesis [ 2- 4].
In mammary gland development and tumorigenesis fibronectin is involved in motility and branching morphogenesis [ 6].
Using the gene ontology (GO) term 'enrichment', we found that four out of the top five over-represented classes of genes are directly linked to cilia, including 'ciliary or flagellar motility' and 'cilium morphogenesis' (GO 0001539 and GO 0060271; Fig. 1C).
Interestingly, in situ hybridisation demonstrated that TNC-AD1 mRNA is abundant at sites of cell motility and branching morphogenesis, suggesting that inclusion of this repeat may contribute to the migration-promoting effect of TNC [ 31].
HGF acts as a pleiotropic factor and cytokine, promoting cell proliferation, survival, motility, scattering, differentiation and morphogenesis.
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motility and morphology
motility and apoptosis
motility and mortality
motility and prostate
motility and percentage
motility and metastasis
motility and plasma
motility and ciliogenesis
motility and biocompatibility
motility and soma
motility and excretion
motility and differentiation
motility and sperm
motility and adhesion
motility and drug
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