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Taken together with EMT-phenotype, these results may explain the increased cellular motility and matrix invasion of HCC cells.
HGF stimulates mitogenesis, cell motility and matrix invasion, and thus it has a central role in angiogenesis, tumorigenesis and tissue regeneration [ 19].
To explore the molecular mechanism by which HOTAIR contributes to the invasion and metastasis of NSCLC, we investigated potential target proteins involved in cell motility and matrix invasion.
To explore the molecular mechanism by which SPRY4-IT1 contoibuthe to the proliferation and metastasis of NSCLC, we investigated potential target proteins involved in cell motility and matrix invasion.
In this study we provide functional data that CCN5 is capable of inhibiting processes in cultured VSMC that are thought to be important in the pathogenesis of arteriosclerosis and restenosis: motility and matrix modification.
Not only do these microplate methods measure three-dimensional tumor growth, but they have also been significantly enhanced to facilitate a range of functional assays exemplifying additional key hallmarks of cancer, namely cell motility and matrix invasion.
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A major downstream target of inflammatory cytokines is the transcription factor nuclear factor-κB, and its sustained activation in FLS/MSC cultures was sufficient to inhibit osteogenic and adipogenic differentiation and at the same time to enhance proliferation, motility, and matrix-degrading activity [ 12].
In this study, we demonstrated that knockdown of IMP3 impedes motility, invasion, and matrix adhesion of pancreatic cancer cells.
This effect is likely due to increased translation of mRNAs that contribute to motility, invasion and matrix adhesion including CD44 and KIF11.
The observed decrease in motility, invasion, and matrix adhesion of Hs766T following IMP3 knockdown suggests that IMP3 facilitates the pro-metastatic behavior of a sub-set of pancreatic cancer cells.
Focuses on membranes (structure, function, traffic), organelles, the cell surface, signal transduction, cytoskeleton, cell motility and extracellular matrix.
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