Sentence examples for motility and invasive from inspiring English sources

In conclusion, metastin (45 54) may have potential therapeutic use by suppressing the motility and invasive ability of RCC cells which possess hOT7T175 with either a negative expression or very low expression level of KiSS-1 through, at least in part, the down-regulation of MMP-2.

Interestingly, HCT116 showed a higher motility and invasive potential than HT29 cells (Figure 5, panels B and C).

Immortalized prostate stromal cells (WPMY-1) and tumor-derived, primary stromal cells (not shown) also formed stellate-like structures, however lacking rapid motility and invasive properties.

The evidence is accumulating that prolonged induction of EMT plays an important role in cancer progression by converting immobile epithelial cells into fibroblast-like cells with reduced intercellular adhesion, increased motility and invasive behavior of cells [15] [18], [20], [21].

It may well be that these transformed cells are hybrid cells with some mesenchymal properties, as evidenced by their expression of vimentin mRNA and protein, that confer motility and invasive capability.

Dysregulation of Src has been linked to oncogenesis process for many years [52], and it is also known to play a role in metastasis by modulating cell motility and invasive abilities in skin, breast and colon cancers [53].

Biologically, knockdown of TβRIII in TNBC MSL cell lines resulted in decreased motility and invasion, a lack of invasive protrusion in three-dimensional culture in vitro and a significant decrease in tumor growth in a xenograft mouse model.

Thus, our results indicate that fascin overexpression leads to increase in cell motility, tumorigenicity and invasive potential of OSCC cells.

In addition, knockdown of JMJD6 in invasive cell lines, such as MDA-MB231, decreased motility and invasion, whereas overexpression in MCF-7 cells slightly promoted motility but did not confer invasive growth.

Next the cell motility and the invasive capacity of MCF-7/c-Jun cells were analyzed in a classical wound migration assay.

These results indicate that vincristine activates GEF-H1/RhoA/ROCK/MLC signaling, thereby promoting amoeboid-like motility and the invasive ability of MKN45 cells.