We find that eHsp90 signaling is essential for sustaining AKT activation, P-EphA2S897, lamellipodia formation, and concomitant GBM cell motility and invasion.
The increased MT-based dynamics and concomitant decrease in actin-based motility of caveolae suggest that cytoskeletal defects might underlie the abnormal caveolar targeting in ILK-K5 cells.
Interestingly, silencing Pfn1 expression is associated with downregulation of both cell cell and cell matrix adhesions with concomitant increase in motility and dramatic scattering of normal human mammary epithelial cells.
We propose that in these breast tumour cells this reciprocal antagonism between RhoA and Rac1 precisely coordinates the specificity and/or magnitude of the pathophysiological response of NHE1 to serum deprivation, with concomitant increases in motility and invasion and hence malignant progression [ 6].
Will it be able to sustain that – and concomitant growth – on a single stage?
With each and every right comes an equal and concomitant responsibility.
Hepatocyte growth factor also dramatically enhanced SCLC cell motility with concomitant induction of tyrosine phosphorylation of a number of cellular proteins such as the focal adhesion proteins paxillin, focal adhesion kinase (FAK), and PYK2.
Previous and concomitant therapies were documented.
Concomitant decrease in the fish spermatozoa motility and velocity was also shown at the same concentrations, and a dramatic increase in DNA fragmentation was recorded by Comet assay (Hulak et al. 2013).
Renal transplant patients, however, exhibit a higher rate of tacrolimus clearance than healthy volunteers (3), possibly due to low hematocrit and albumin levels, concomitant administration of corticosteroids (4) and high rates of disturbed gastrointestinal motility and diabetes.
