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In addition, we searched for novel sequence motifs utilizing the whole data set without the need to dichotomize exons into AE and CE by applying the correlation-based method REDUCE [ 50] to the splice site proximal sequences and our exon-level score for measuring exon skipping (n = 83789).

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Gene expression data can also be used to discover DNA-binding motifs utilizing ab initio motif discovery from the promoters of sets of co-expressed genes (Roven and Bussemaker, 2003).

Advances in unnatural amino acid incorporation into proteins have enabled the convenient functionalization of relevant proteins to a broad array of chemical and biochemical motifs utilizing azide alkyne cycloaddition, or "click" chemistry.

To identify the motifs utilized for TR4 recruitment at the 346 TR4 binding sites that are also occupied by ELK4, we performed motif analysis using MEME.

The docking motifs utilized in each of the three MAP kinases sensors are listed in Table 1, which shows that each manifested at least a 70-fold enhanced affinity for the MAP kinase subfamily of interest.

For example, Eps15 and S5a, which each have two UIM motifs, utilize K48, A46, and I66 residues, centered around I44 in the Ubl domain, for binding.

Taken together, this indicates that XPB helicase employs a rotatory mechanism to move along DNA during which the RED motif opens dsDNA utilizing the energy from ATP hydrolysis.

We first describe common network motifs that underlie cellular adaptation and homeostasis; these motifs utilize negative feedback and incoherent feedforward loops.

To determine whether downregulated responsive genes shared common cis-regulatory sequence motifs, we utilized the Pathway Studio software package to examine their promoter regions (2 kb up- or downstream of the transcriptional start sites) for known TF binding-site motifs.

To predict upstream kinases for identified phosphosites, in-house software utilizing the kinase motifs listed on human protein reference database was used.

Here we report the design and construction of polyfunctional RNA square architectures utilizing the 3WJ motif of bacteriophage phi29.

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