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To find motifs that differ in frequency between different regulatory modes, the redundancy ratios of genes with and without each motif were compared using Wilcoxon's rank-sum test.
The diploid genome allows us to identify binding motifs that differ between alleles and that correspond to differences in chromatin accessibility.
Each σ factor recognizes promoter motifs that differ in their consensus DNA sequence.
In fact, motifs that differ in one, two and three base pairs from the four never-found human nullomers occur with increasing frequencies consistent with the effects of CpG hypermutability.
However, motifs that differ from this standard have been observed from natural outbreaks of H7 HPAI (16 ).
To determine the mutational behavior of repeats of various sizes, we further engineered the HSV-tk gene to contain a series of tandem [GT/CA] motifs that differ in increments of one unit, from 4 through 13 units (fig. 3).
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All target genes had this core binding motif present in their upstream sequences except for two of the ten target genes, which had binding motifs that differed from the consensus binding motif in two nucleotides, namely, TTTTAAC and AGTTTCC.
Interaction with PCNA is mediated by a PIP-like motif that differs somewhat from the canonical version in terms of sequence and conformation, whereas the SIM SUMO interaction closely resembles that of other known examples.
The only exception was tetraodon, which had a preferred SP1 motif that differed from the GC box at two nucleotide sites, most commonly appearing as a variant similar to the GA box (AGG AG G.
We demonstrate that enhancer activation depends on cis-regulatory motif combinations that differ between cell types and can predict cell-type-specific ecdysone targeting.
Reinitiation events that take place at either the authentic or the downstream stop-start motifs would produce polypeptides that differ in size by only 13 amino acids, thus we would not expect to be able to distinguish them by SDS-PAGE, and this is clear in Figure 6, where the reinitiation products show very similar electrophoretic mobilities.
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