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In addition, the proximity of the negatively regulating motif around tyrosine Y759 to the different STAT3-recruiting motifs does not seem to be responsible for their differential capacity to activate STAT3.
Moreover, we showed that integrating the PSSMs with our motifs does not improve the accuracy of our Ste20p substrate predictor.
Indeed, the identification of the feedforward and bifan motifs does not allow us to determine how these motifs are used, or how they contribute to the worm's behavior.
Please note that the orientation of local motifs does not affect the comparison.
Nonetheless, the presence of in silico predicted binding motifs does not guarantee a specific regulatory factor will bind that sequence.
112 Despite strong homology in the dystrophin genes of human, mouse, and dog, directing AOs to the pre-mRNA motifs does not necessarily induce comparable exon skipping.
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Moreover, although grass genomes are G/C rich, the sequences in grass SSR motifs did not show a similar pattern.
Surprisingly, we show that heteroclitic peptides designed with optimal MHC binding motifs do not always form pMHCs that are substantially more stable than their wildtype progenitors.
Presence or absence of CArG motifs did not correlate with promoter response to radiation.
The incorporation of these functional motifs did not prevent the designer peptides from forming well-ordered nanofibers using SEM examination.
We note the ZNF274 motifs do not have high similarity to binding sites of other factors, but we did identify several quite long motifs.
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