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Despite their low sequence similarity, three out of four motifs are shared with T7 RNAP that recognizes a double-stranded DNA promoter.
The theme encompasses the aspects of the Mediterranean as a cauldron of creativity where influences and motifs are shared, exchanged, altered and incorporated.
In addition, many TF-binding motifs are shared between these two unique clusters.
Several of the enriched promoter binding motifs are shared between the prostate epithelial/mesenchymal compartments and their epidermis/dermis counterparts, indicating their likely relevance in epithelial/mesenchymal signaling in primitive cellular compartments.
Accordingly, LRP-1 ICD NPxY motifs are shared by integrin-β tails and LRP-1 was shown to bind a talin homologue and the integrin cytoplasmic associated protein ICAP-1 [64], [64].
The promoter sequence analysis indicates that some of the enriched binding motifs are shared by gene sets of the prostate and the skin, among them the binding site of TFII-I, Srebp1, Maz and Lmo2 (Tables 1, 2).
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According to the conserved motifs found with MEME, nine motifs were shared by insects of 13A1 family but eight in 13A3 family.
However, some motifs were shared between members of different clades.
Certain motifs appeared in specific groups and some motifs were shared by several groups.
Ten of these cis-regulatory motifs were shared by several of the upregulated CP- and muscle-related genes.
Among these, 8 motifs were shared by both the C2- and PXPH-PLDs subfamilies, implying that they may be necessary for PLD function.
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