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We introduce tools for the analysis and design of robust homeostatic circuits and propose a new regulation motif, which we call antithetic integral feedback.
This suggests that the novel motif, which we derived from downstream sequences of experimentally supported miRNA target sites, is functionally connected with the miRNA target site biology.
We also validated the binding of OCT4 to an evolutionary conserved OCT4 motif, which we found in the proximal promoter region of the USP44 gene.
Further, we describe the separation of the ALP and Enigma subfamilies in lower vertebrates and identify a novel consensus motif, which we call 'ALP-like motif' (AM).
We found this motif, which we termed FORCA, to exhibit DNA sequence specific and differential interactions with nuclear Arabidopsis proteins.
In particular, an FFC comprising two repressors that are both autoregulated was revealed as a significant network motif, which we termed the double-autoregulation FFC (DAR-FFC).
Similar(46)
Previously, we identified two novel tubulin-binding motifs, which we mapped to the C-terminal cytoplasmic domain of TRPV1 [36] [37].
In Table 1, we list the number of theoretically possible motifs as well as the number of non-zero motifs which we have identified in each dataset.
Thus, based on this algorithm, we wondered what the correlation of octamer motifs (which we will refer to as the OCT4 motif) and the peak score value would be.
As further statistical validation, we find that the BPM motifs which we predict from the smaller Kelley and Ideker interaction network are consistently carried forward on the larger BioGRID network.
Specifically, the Asp and Phe of the DFG-motif, which we defined as the (D) and (D + 1) residues (Methods), respectively, are flipped by approximately 180° in relation to DFG-in structures, whereas the side chain of the (D + 1) residue points away from the hydrophobic DFG-pocket.
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