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Comparison with the previously reported structures revealed that our structures adopt basically identical fold but display significant differences in the wing motif, which could account for the difference of PTM patterns between HSF1 and HSF2 (Anckar et al., 2006, Jaeger et al., 2016).
Since the minimal Epo promoter contains an E-box motif, which could represent a binding element for the transcription factor heterodimer CLOCK∶BMAL1 as the major circadian regulator, we tested herein the hypothesis that these factors could be involved in diurnal oscillation of Epo mRNA expression.
This could be due to compound formations containing more than one SSR motif, which could increase the probability of polymorphism.
One interesting similarity between Thaps3_25838 and 24597 is an MSMSM motif, which could have a yet to be determined common function.
Blends of 1 and 2 were found to adopt a single packing motif, which could be identified as corresponding to that of compound 1 (form A), whereas other blends showed new packing motifs not seen for either pure gelator.
The next step in a systems biology approach would be to develop a mathematical model for such a GRN motif which could generate the proper gene expression patterns in the biological tissue geometries.
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We searched for proline-rich (PxxP) motifs which could bind to the SH3-domain of the β-subunits.
We focused on the functional role of non-pathologic Atx1 and set out to identify sequence motifs which could provide direct information about the mechanisms involved in recognition.
Aur-A has four putative D-Box and one KEN box motifs, which could potentially be recognized by the APCCdh1 ubiquitin ligase complex.
It should be noted that one PFM from the FORKHEAD family (FOXL1) was clustered with five MADS motifs, which could be explained by the fact that TFBSs for FOXL1 contains only 3 information-rich positions, which resembles partial MADS TFBSs.
Our analysis revealed motifs which could be responsible for light-dependent regulation in every gene.
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