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When comparing the autolytic sites to the motif we found that all identified autolytic sites strongly resemble the first motif ([LIMV]X(2 4)[LIMV][DEQ]). We did find another peptide within CAPN3 that was functional in our biochemical system and may represent a new autolytic cleavage site.
When we assessed all 26 tested photoreceptor CREs for the presence of this motif, we found that it was present in the following percentage of CREs: 100% (4/4) of 'very strong' CREs, 17% (1/6) of 'strong' CREs, 25% (1/4) 'medium' CREs, and 0% of 'weak' (0/5) and 'absent' (0/7) CREs (Fig. S3).
In addition, the motif we found shows partial coincidence with the one obtained by SELEX [ 57].
Of the co-regulation motif we found six types of regulatory and two types of activation/inhibition motifs to be significantly over-represented.
These results indicate that the high-affinity 10-mer motif we found is even more dominant factor that alone can stabilize K d at a low level.
Despite the gradual divergence of genetic sequences surrounding the core CTCF sequence motif, we found evidence that multiple repeat sequences have carried CTCF binding in common ancestors.
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All the ballad can say is that its hero avoids picking on the needy or on women – a motif we find in most bandit ballads (including those extolling Lampion or the ruthless Jesse James), and which slowly accrued substance through the following century.
Thus, based on our elucidation of the CAPN3 cleavage motif we find explainable disturbances in the levels of two predicted substrates in patients.
In addition to multiple TAAT core motifs we found two CTAATTG motifs in AmphiChordin promoter at positions −574/−580 and −687/−682 (Fig. 8A and data not shown).
In our search for additional functional motifs, we found that a class of bone marrow homing peptides BMHP [20] could be one of the most promising family candidates for stimulating NSC adhesion and differentiation.
By aligning the sequences of TF monomers with the consensus sequence of the YY1 motifs, we found that 17% (48/290) of TF elements from gene-rich regions and 11% of TF elements (58/529) from intergenic regions contain mutations within the putative YY1 binding site of a 'minimal' promoter that is composed of only two monomers (Figure 5).
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CEO of Professional Science Editing for Scientists @ prosciediting.com