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A recurrent musical motif using a bowdlerised pop version of Beethoven's 7th strikes a typically jarring note – at once cheesy and disposable, yet still lingering and profound.
These results show, for the first time, the molecular mechanism for reduced immunogenicity for the buried-ligand architecture and feasibility of targeting with this motif using a physiological ligand receptor pair.
A gene, LeCBP encoding a protein containing a PHD zinc finger motif and a bipartite nuclear localization signal, was identified from tomato pistils by its binding ability to a specific DNA motif using a yeast one-hybrid system.
The computational purpose of a feed-forward motif using a bi-directional gap junction is not immediately obvious, but it is possible that this back connection (or many back connections) are meaningful in information-processing by providing the opportunity of feedback.
In a program called poladq, Tabaska and Zhang [ 8] included the DSE motif using a quadratic discriminant function.
ChIP assays were carried out using the ChIP-IT Express EnzymActiveit (Active Motif) using a dounce homoginizer to lyse cells.
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By contrast, the chromodomain comprises three antiparallel extended β-strands reinforced by a cross-strand helix that forms a methylated chromatin-binding motif using an aromatic cage [ 12].
Hence, the Rer1p-binding motif uses a similar 'hide and run' strategy to support multiprotein complex assembly.
The AT-hook motif uses a conserved palindromic core sequence, Arg-Gly-Arg, to bind to the minor groove of AT-rich B-form DNA.
We then compute the similarity between two motifs using a distance measure between their corresponding KFVs.
To investigate if most of our targets contain an octamer motif, we screened all the peak regions of 497 target genes for OCT4 motifs, using a peak-score of 0.5 and ranked them based on a significance score.
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