Your English writing platform
Free sign upExact(11)
Intra-molecular hydrogen bonding was introduced to the quinazoline motif to form a pseudo ring (intra-molecular H-bond scaffold, iMHBS) to mimic our previous published core structures, pyrido[2.3-D]pyrimidin-7-one and pteridinone, as PI3K/mTOR dual inhibitors.
To summarise, the tape formed by the binary synthons ({text{R}}_{2}^{2} 8)·[>a>g] and ({text{R}}_{2}^{2} 8)·[>b>f] is created using triamterene A and B molecules and creates hydrogen bonded dimers linked by further hydrogen bonded chains with the C[6] unitary motif to form a ribbon.
For the negative datasets, which are 20,000 random protein pairs, we threw one of each protein pair into Minimotif Miner (MnM) [1], [2] as the source query protein and found its motif to form the triple of motif, source protein and target protein.
Given a 1D motif, SeqFEATURE algorithm automatically extracts structures from the PDB that contain the motif to form a positive training set.
In the basal state, newly-translated Nrf2 binds to one member of a free Keap1 dimer through its high affinity "ETGE" motif to form the open conformation.
Prior to the divergence of extant embryophytes, the PPC domain became associated with a Type-I AT-hook motif to form a primitive intron-less AHL gene.
Similar(49)
PHEX binds to the DMP1-ASARM-motif to form a trimeric-complex with α5β3-integrin on the osteocyte surface and this suppresses FGF23 expression.
Meanwhile, each of 2-D bilayers is interlocked by four adjacent identical motifs to form three-dimensional (3-D) 5-fold interpenetrating conformation with weak Ag···Ag interactions.
It was a slow process catalysed by the Venerable Bede, whose Ecclesiastical History of the English People used biblical motifs to form a national narrative, and subsequently by King Alfred.
For example, Niemeyer et al. used DNA protein conjugate motifs to form linear protein arrays [148, 151 153].
It's possible that certain stressors can cause the acidity of the cell to change and prompt an i-motif to form.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com