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Our motif search method and most other motif search methods only utilise sequence data.
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Although motif search methods such as [ 26] identify sequences that are similar to previously determined enhancers and silencers, most computational approaches require as input a large collection of alternatively spliced exons.
The branch site and polypyrimidine tract for each intron were identified using a motif searching method implemented in a self-written PERL script, as described in previous studies [ 28, 31].
Many traditional motif-searching methods, such as Meme [ 22], are not designed to accommodate phylogenetic structure, and therefore in this context, tend to report motifs that arise from conservation within subfamilies we already knew about.
Protein motif searches (see Methods) were done for each of the hypothetical proteins in a quest for additional functional information.
All the promoter sequences from differentially expressed genes were achieved from both BT×623 and Keller genomes and were then submitted to motif searches (see Methods).
In order to test these two interactions and to see if the Northern blots findings are a result of a physical interaction, we predicted SrbA binding sites using motif searching (see methods).
Therefore, the SNP-containing motifs that act as TFBS reveal novel regulatory events that cannot be identified using traditional motif search and selection methods.
We have combined protein motif search and gene finding methods to identify genes encoding proteins containing specific domains.
To that end, we formulated a straightforward frequency-based scheme to score similarity and implemented the scheme in a similar motif search (SMS) tool (see methods).
To identify motifs in our DC signaling network, we used a fully connected directed graph that was reconstructed from our DC map, as described in detail in Additional file 1, followed by a motif search using several detection methods [ 78- 80].
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