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Genes regulated by those promoters are expected to be a regulon of the housekeeping sigma factor (SigA) and the promoter motif is quite similar with that identified in the previous studies31,42.
The motif is quite similar to Human PKA motif; further bioinformatic analysis reveals the presence of such motif in many reported STPK substrates (File S1).
This motif is quite conserved but there are exceptions.
Our derivation of the regulation equation for TI motif is quite similar to presentation given for TD motifs in [ 20], but has several changes in assumptions and formulations.
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Although regulation was relatively modest, the motif was quite well-conserved across kinetoplastid evolution.
The length of the DBD motif was quite variable with the smaller size observed for MdHsfB1b.
There is the case that a motif is conserved across tissues, while the genes that constitute the motif are quite different in different tissues.
The leader sequences (taken as the amino acid sequence before the GG motif) have a range between 66 85 amino acids, whilst the core sequences, taken as the amino acid sequence following the conserved VAGG or VSGG motif, are quite variable in length (14 59 amino acids) (Table 7, Figure 8B).
MYB-related motifs are quite diverse, but can be classified into two classes.
The exon/intron layouts and the TM motifs were quite conserved when compared to the paralogs.
The enriched motifs are quite different in both datasets, indicating that there are multiple regulatory avenues to regulate the RNA methylome through sequence specificity.
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