Sentence examples for motif is mutated from inspiring English sources

We expressed the mutant CED-7(D1691A), in which the Asp-1691 sine in the DQXD motif is mutated to alanine (Fig. 6a), and found that it was unable to rescue the defect in axon regeneration observed in ced-7(n2094) mutants (Fig. 5e and Supplementary Table 1).

Named PTP "substrate-trapping" mutants by the Tonks laboratory, they represent a diverse variety of defective PTPs that are epitomized by the Cys to Ser mutant (C/S) where the active cysteine residue of the signature motif is mutated to a serine residue.

Clearly, if this motif is mutated, AC8 is not processed or N-glycosylated appropriately.

This species contains one tRNase ZL-like protein in which the second His in the His motif is mutated to Gln (data not shown).

When the LXXLL motif is mutated to LXXAA, WT ACTN4 (LXX AA) exhibits significant loss of the ability to potentiate RARα mediated transcription.

We constructed a kinase-dead JNK1- DN mutant K55R, in which lysine-55, which is critical for phosphotransfer in the ATP-binding motif, is mutated to arginine and generated stable transfectants in ZE cells.

Competition experiments with unlabeled probes containing mutations of conserved nucleotides showed that Zfp335 binding was abolished when both DNA elements of the bipartite motif were mutated, whereas mutations in either the first or second element had an intermediate effect, indicating that both parts of the consensus motif are required for full Zfp335 binding.

To further understand the specificity of these interactions, the E-box motif was mutated and the interaction between the TFs and the mutated motifs were investigated using yeast one-hybrid analysis.

A peptide nanowire of 33 amino acids, comprised of a leucine zipper motif, was mutated to bind divalent metals, conferring conductivity into the peptide.

However, when the Sp1 motif was mutated no such Sp1 mediated enhancement in luciferase gene was seen (Figure S3B, compare bar 2 and 3 with bar 1).

Importantly, the lethal effect of D-CblL was significantly reduced when the Drk binding motif was mutated in D-CblL (Table 2).