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The chief partnering motif involves a woman — often, the diminutive Maxim-Jo Beck McGosh — running at full speed into the arms of a man.
The most commonly employed strategy to access this motif involves a double Wittig olefination between a C10-trienedialdehyde and two C15-polyenylphosphonate salts, which typically leads to mixtures of olefin stereoisomers.
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A less common motif involves an additional aspartate or glutamate residue as the fourth residue in the pentapeptide, whereas another motif, which interestingly is more common in the cluster of CR domains that binds the fewest ligands (cluster III), is DxxxD [ 10, 13].
The novel gives the concept some low-key metaphysical play — original sin is an obvious analogy — but, apart from this and a death-and-resurrection motif involving a saxophonist in a surf-rock band, "Inherent Vice" does not appear to be a Pynchonian palimpsest of semi-obscure allusions.
But the rest of the story labors under a rather mawkish "Touched by an Angel" motif involving a peculiar visitation of the Virgin Mary in the woods under the gaze of a family of deer.
The canonical binding mode of PDZ domains to target motifs involves a small interface, unlikely to fully account for PDZ-target interaction specificities.
The Rad51 structure reveals a polymerization motif involving an interdomain linker key for quaternary assembly.
We have applied a novel methodology to the prediction of C-terminal-anchored peptide motifs involving a simple z-statistic and several techniques for improving the signal-to-noise ratio.
Consider first a TD-motif involving an mRNA gene G, a protein P, an miRNA M, transcription repressive proteins R1, R2,…, and transcription activating proteins A1, A2,….
Finally, the feedback (FB) motif involves stimulation of a reaction by a signal, followed by end-product regulation (positive or negative) of the process.
This motif type involves a self-regulated gene.
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