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This was expanded to a small biased library of compounds mimicking the 'ZRXL' motif in order to identify E2F-1/Cyclin antagoniststs.
Our goal is to modify the P3 site of this motif in order to identify the structural requirements for the interaction with the target.
The study presented here focuses on a single motif in order to isolate its contribution to expression level in a controlled experiment.
This might reflect the need for binding to the PACS sorting adaptor via this motif in order to target the receptors to this compartment.
Each matrix stores the frequency for each nucleotide at every position of the putative motif in order to summarize the alignment information for the TF with a binding site.
Next, we focused on NLS2 motif in order to characterize the NLS motif within VP2.
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Once again, the novel inhabits conventional motifs in order to renovate them.
Chutti – painstakingly cut out paper beards or ridges – are then added to the geometrically precise makeup motifs, in order to broaden the face with fantastic jowls.
The clustering algorithm works in an origin-shifted four-dimensional space based on the two φ,ψ pairs to yield a parameter-dependent list of 2 motifs, in order of their prominence.
Ester and carbamate linker groups as well as oligomethylene spacers of various lengths were used to connect cholesterol and spermine motifs in order to estimate the structure-activity relationships of novel polycationic lipids and to determine an effective and safe transfectant suitable for the delivery of different nucleic acids.
We functionalized RADA16 with three biologically active motifs in order to develop a second generation of self-assembling peptide scaffolds to closer mimic extracellular matrices that enhance pre-osteoblast cell maintenance and function in vitro.
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