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We also used motif finding algorithms to find potential consensus site for single base pair substitutions.
A widely used model is to cluster genes based on their expression profile and then using motif finding algorithms [ 7- 14] or motif enumerators to find the over-represented sequences within each cluster [ 15- 18].
First and most importantly, PSO+ differs from other motif finding algorithms by explicitly modeling gaps, which provides an easy solution to find gapped motifs.
PSO-EM simply uses PSO to find candidate motifs, which are then used as seeds by other expectation-maximization based motif finding algorithms, such as MEME [ 2].
Many motif finding algorithms, for example references [4] [15], have been developed and the performance of motif finding algorithms has been steadily improving.
Probability model-based de novo motif finding algorithms like MEME can be sensitive [59], [60], but may be too slow when thousands to tens of thousands of enriched regions need to be analyzed.
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First, when using long DNA sequences, the computations of the motif finding algorithm MEME take too much time.
TRANSMODIS is not a motif finding algorithm rather it focuses on determining direct targets of a TF.
We used the motif finding algorithm MEME, to search exonic or intronic RNA fragments for over represented sequences [20], [21].
Search for over-represented sequence elements in 5'UTR and 3'UTR regions was performed using an enumerative Markov chain motif finding algorithm [68], which applies z-scores to evaluate the over-representation of exact DNA words, and SiteDB program [69].
Cawley et al. [ 60] note that the motif finding algorithm MDscan [ 22] recovers the known Sp1 binding motif from their data.
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