Sentence examples for motif failed to from inspiring English sources

Further, SGK lacking a PY motif failed to stimulate ENaC activity in the presence of Nedd4-2.

Smaller deletions within the PEST motif failed to block calpain cleavage of SMN (Fig. 2C), suggesting that the entire PEST motif is not necessary to direct calpain cleavage.

Moreover, OsLIC with a truncated CCCH motif failed to bind any nucleic acid, which indicates that the CCCH motif is required for its nucleic acid binding activity (Figure 8B).

Moreover, these data also verified that a fourth tyrosine located at amino acid position 544, which does not fit a typical signaling motif, failed to be pTyr.

Among them, two mutants, G2A, which lacks a myristoylation site, and AxxA, which carries a mutation in its proline-rich PxxP motif, failed to activate MAP kinases and NF- κB pathway.

Activation of the RRM2 promoter by HPVE7 requires the interaction between HPVE7 and pRB because a mutant HPVE7 with a deletion of the pRb binding motif failed to transactivate the RRM2 promoter.

This is consistent with our previous study showing that the expression of mammalian FMRP mutants lacking the RGG motif fails to induce granules in fmr1−/− MEF cells (Mazroui et al., 2003).

The control ODN 2138 (10 µg/ml), which contains GpC motifs in lieu of CpG motifs, failed to stimulate cytokine release.

Stimulation of DCs with oligonucleotides lacking CpG-motifs failed to induce IL-12 production compared to CpG-containing oligonucleotides (P<0.0001).

However, although this domain contains two putative nuclear localization signals, mutation of these motifs failed to prevent nuclear localization [ 14].

In contrast, an AMOT p130 protein that lacked the three N-terminal PPXY motifs failed to rescue NEDD4L-dependent HIV-1ΔPTAP, ΔYP release.