Although water is vital for life, the structure of this water in the cytosol is not well understood, mostly because methods such as nuclear magnetic resonance spectroscopy only give information on the average structure of water, and cannot measure local variations at the microscopic scale.
The frequency of ATM mutations in large series of CLL patients it is not so well understood, mostly owing to the fact that its size and the scattered distribution of its somatic mutations precludes the drafting of an amplicon-limited design.
In mammals, the intracellular sorting pathways for newly synthesized lysosomal proteins are well understood and depend mostly on the action of two M6P receptors: the M6P/insulin-like growth factor II receptor (M6P/IGF2R) and the 46-kDa M6P receptor (MPR46).
As the molecular causes of AF are not well understood, current treatments are mostly empiric.
The mysticism of their methods is mostly well-understood and usually starts with someone taking a huge risk before they started to apply scientism to their thinking.
The reasons why are not well understood, and the answers put forward by experts are mostly anecdotal and sometimes contradictory.
The genetics of inherited hearing impairment is rather well understood; it is heterogeneous, typically monogenic and caused by rare, highly penetrant, and mostly disabling mutations (http://webh01.ua.ac.be/hhh/).
This dynamic is well understood.
