In HGPS, which arises from a silent de novo mutation in exon 11 of LMNA, progerin is found mostly in tissues of mesodermal origin and it has been suggested that it may also play a role in the 'natural' ageing process in tissues.
In our panel that mostly contains tissues of mesodermal origin, heteroplasmy at position 16,093 differed by more than 40%% between two mesodermal derivatives bone marrow and lienal artery.
PCR amplification detected proviral LTR DNA mostly in tissues of the CNS (SC and CPx), whereas samples from L or MG yielded few positives and inconsistent results, respectively.
In the beginning of miRNA research mostly tissue has been in the focus of research, thus for all human tissue types specific profiles have been discovered, e.g. from patients with lung cancer [ 4], breast cancer [ 5] or glioblastoma [ 6].
EHE occurs mostly in soft tissues of the extremities and various visceral organs (lung, bone, brain and intestine, etc).
Previous studies have demonstrated that normalization of miRNA expression, mostly of tissue-specific miRNAs, could be used as differentiation therapy in RMS.
Levels of proliferation marker Ki67 were mostly unchanged in tumour tissues of PyVmT/Usp18 KO deficient mice (Fig 2).
Studies of miRNAs in cardiovascular diseases have mostly been based on tissues of disease models [ 41, 44, 45, 49] and transgenic mice [ 39, 40, 44, 46].
Other pig derivatives include industrial materials such as pharmaceutical-grade heparin, which is mostly derived from mucosal tissues of the pig small intestine.
After the menopause, when ovarian production of both estrogen and progesterone ceases, the major source of estrogen is via peripheral conversion, mostly within adipose tissue, of androgens that continue being produced by the adrenal glands and ovaries.
