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While BPs [ 14, 15] and other antiresorptive agents [ 5- 7, 16] have shown promise, mostly structural effects (inhibition of cartilage degeneration [ 12, 14], prevention of osteophytes [ 14] and reduction in bone marker turnover [ 15]) in animal models of OA with pre-emptive treatment, clinical results in knee OA patients have been disappointing, for example, with risedronate [ 17].
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The implemented ones are mostly structural party changes, and the ideas that have been ignored are mostly suggested policy changes.
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A comprehensive numerical investigation with rate insensitive constitutive laws is also performed to model the experimental results for different cell size/wall thickness/base material, which suggests that honeycomb crushing pressure enhancement under impact loading is mostly due to a structural effect.
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