In contrast, 85% of X-linked and 84-88% autosomal genes are expressed in the mostly somatic cell type A. Moreover, 12.4% of X-linked genes are expressed mostly in the post-meiotic deconvolution cell type E, a proportion that is lower than that for autosomal genes (13.3-17.5%).
In E13.5 female gonads, levels of Rad54 mRNA in stage-specific embryonic antigen 1 (SSEA1 -positive cellSSEA1 -positiveioticellsm cells) were also higher than in SSEA1-negative cells (mostly ovarian somatic cells and some meiotic germ cells) (not shown).
However, some showed mosaic expression of GFP in somatic cells, mostly in muscle or skin [ 13].
Somatic cells mostly adopt the error prone non-homologous end joining (NHEJ) pathway to repair DNA damage [39].
Cellular replicative senescence was originally referred to as a proliferative end stage in cultured somatic cells (mostly fibroblasts).
However, it must be kept in mind that CO happens at meiosis, when chromosome are highly compacted, while BR occurs in somatic cells mostly during mitotic interphase, when chromosome landmarks are hard to observe.
However, the role of PRC2 in lineage-committed somatic cells is mostly unknown.
In somatic cells, transposition mostly uses a "cut-and-paste" mechanism.
In contrast to germ line retrotransposition, the activity of Alus and other mobile genetic elements in somatic cells is mostly silenced by DNA methylation and post-transcriptional mechanisms mediated by piwi-interacting RNAs, siRNAs, miRNAs and AID/APOBEC gene family members [ 5, 15- 18].
Importantly, LCPs were shown to be mostly methylated, whereas the vast majority of HCPs are hypomethylated in somatic cells (Weber et al. 2007).
