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HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin.
Lin28b is mostly nuclear, with a specific localization in the nucleolus.
GR expression in TNBC single-tissue samples and TMA cores was characterized as mostly nuclear, with some concurrent cytoplasmic reactivity.
In LTL-418 tumor xenograft BIRC5 expression was mostly nuclear with a mix of nuclei with high and low staining (Additional file 5A).
The families were mostly nuclear, with 77% with three or more women, and 19% with four or more women with complete analysis information.
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GR expression in TNBC single-tissue samples and TMA cores was characterized as mostly nuclear, but sometimes with concurrent cytoplasmic reactivity.
Another related styryl molecule, D123 (Figure 3, Compound 10), exhibited mostly nuclear staining (Figure 4G), with diffuse staining in the cytoplasm, and the fluorescence of signal of the compound being mostly detectable in the TRITC channel (Figure 4H).
In stage 5 flower buds, the initiating petal and stamen primordia revealed an epidermal layer with mostly nuclear SEP3 GFP, while the subepidermal and inner cell layers showed a lower SEP3 GFP signal, both cytoplasmically and nuclear localised.
The uniform finding is a correlation of upregulated, mostly nuclear YB-1 expression with poor outcome, e.g. early relapses and tumor growth, suggesting high YB-1 expression is an independent negative prognostic marker for many solid tumors.
The mostly nuclear AFLP data are concordant with field identification of the samples but conflict with mtDNA haplotypes.
The overexpression of (mostly nuclear) YB-1 has been associated with poor outcome, e.g. early relapses and aggressive tumor growth, in several tumor entities (summarized in [ 2]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com