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In all, 29 nonhaematologic side effects, mostly mild (grade 1 or 2) possibly or probably linked with RIT, were reported for nine patients.
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Toxicity was generally mild (grades 0 2).
As known for tyrosine kinase inhibitors (TKI), the most frequent adverse events were any grade of rash (69.3% of the patients) and diarrhoea (41.3%), mostly mild or moderate (rash grades 1-2: 39 patients (52.0%), diarrhoea grades 1-2: 23 (30.6%)).
Regardless of the doses of capecitabine and docetaxel administered, these events were mostly mild to moderate in severity (grades 1 and 2), and grade 3 events were manageable (Table 4).
Side effects associated with sorafenib are mostly mild to moderate, with few severe (Grade 3 4) toxicities.
Eighty-eight (39%) patients with laboratory-confirmed EV71 infection had an uncomplicated disease (Grade 1), such as HFMD, herpangina or simple febrile illness and 61percentt had at least one complication noticed, mostly mild CNS involvement (101 of 224 patients, 45%, grade 2).
Its course has mostly mild clinical signs.
Grade 2 neuropathy was recorded in 3 patients, and grade 1 in 12 patients, thus almost half of the patients (46%) complained of some, albeit mostly mild, neuropathy.
Yet his own habits were mostly mild.
Colors were mostly mild, peachy and pale pink.
He also told me that shoveling snow uphill, even on a mild grade, was counterproductive.
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