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Infectious complications are partially severe but mostly manageable and require particular attention.
The tolerance of the combination was mostly manageable without unexpected toxicity.
Although vinflunine exerted some severe toxicity (most importantly myelosup ion and constipation), these side effects appeared to be mostly manageable.
Many of those chemoradiotherapy combinations include antimetabolites, because of their efficacy, their generally well-defined mechanisms of action and mostly manageable toxicities [ 2].
(32, 33) Diarrhea was mostly manageable but dose reduction or therapy discontinuation was often needed for the patient experienced higher grade diarrhea.
Compared with imatinib, bosutinib was associated with higher rates of gastrointestinal events and ALT/AST elevations; both were mostly manageable with concomitant medication and/or dose modification.
Similar(51)
Moderate diarrhoea was reported in 20 patients and was mostly easily manageable.
Even though there were a lot of concerns regarding toxic side effects of HDACi in the clinical setting due to the roles of HDACs in multiples pathways, until now clinical trials mostly showed manageable side effects.
Moreover, the side effects of the medication, which is given orally, have been manageable — mostly mild nausea and a loss of appetite.
The toxicities, mostly cytopenias, are manageable.
Diarrhoea occurred in >60% of patients at all but the lowest dose level was mostly mild or manageable with loperamide.
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CEO of Professional Science Editing for Scientists @ prosciediting.com