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Tamoxifen altered cell cycle of transduced HepG2 cells, decreased G0/G1 cell numbers, diminished proliferation index and induced cell death mostly in cells overexpressing CYP3A4 but was without significant effect on cytotoxicity or proliferation of cells engineered to overexpress CYP2E1 or on empty vector transfected cells.
Tph1 is expressed mostly in cells of the gut and is responsible for the production of peripheral serotonin [ 9].
In the pons, overlap between pPERK puncta and htau occurred mostly in cells with diffuse, cytoplasmic htau staining rather than dense, fibrillar staining.
In vitro combination studies in different cell lines with either wt or mutant JAK2 or FLT3 also demonstrated synergy, mostly in cells that carried the mutant protein.
Both BRAF RNAi and sorafenib inhibited proliferation in all the cell lines independently of the genetic background, mostly in cells with BRAFV600E mutation.
In contrast, activation of ataxia telangiectasia mutated (ATM) is observed mostly in cells with double-stranded DNA breaks and is one of the proteins activated by ROS that is involved in cell cycle regulation.
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It should be noted that the functional discovery of these miRNAs was made mostly in cell culture systems, which may differ from the in vivo system.
Transcriptional responses of butyrate were studied mostly in cell lines [14], [15], [21] [32] and some studies were performed in animals and human patients [3], [30], [33] [35].
The genes in this classifier are involved mostly in cell growth and protein metabolism.
Only a handful of lncRNAs have been studied to date and mostly in cell culture.
Such autophagic processes occur mostly in cell bodies, and induce neuronal cell death in a relatively short time.
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