Sentence examples for mostly human cell from inspiring English sources

In the lowest (simplest) tier of assessments, evaluations are expected to primarily rely on the results of high- and medium-throughput in vitro screening tests in mostly human cell lines, as well as complementary in silico predictive methods.

It is often assumed any anti-tumor drug activity is due to targeting pathways in the human cells present in the xenograft, and any associated gene expression data is derived from a mostly human cell population.

Whatever the case might be in cancer and stem cells, in mostly normal human cell lines (in particular HEK293 and MCF10A cells) LATS1/2 function downstream of G-protein-coupled receptors (GPCRs) as central controllers of YAP/TAZ activities [ 2].

Thus, the subsequent promoter experiments were mostly carried out using this human cell line.

Therefore, some research groups have used native cartilage explants (mostly human) for studies on the matrix-degrading capacities of synovial cells [ 12, 13].

In human cell lines and mouse primary neurons, the endogenous or over-expressed, wild type FBXO7 isoform 1 displays mostly a diffuse nuclear localization.

Human cell lines were purchased from ATCC.

The sets of genes expressed in human normal liver, HCC and HepG2 cells, glucose, intracellular pathways, or transcription factors modulated by various stimuli were obtained exclusively with human cells, mostly cancer cell lines including HepG2 cells (Table 1).

In every culture, meta-TIFs were predominantly chromatid-type (Fig 2A), indicating that telomere dysfunction in aged human cells mostly results from events during or after replication.

We demonstrated that senescence-related γ-foci in human cells are mostly telomeric, whereas foci in normal mouse cells are mostly non-telomeric.

These data are mostly obtained from experiments in mice and in vitro experiments with human cells.