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These perturbations come mostly from extra-cellular factors.
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MHC-II molecules present peptides derived primarily from extra-cellular proteins, and these are recognized by auxiliary CD4+ T lymphocytes.
Terms from extra-cellular glutamate-gated ion channel to neurological system process to ion transport to axon function are all enriched.
Endometrial epithelial and stromal cell proliferation, as discussed previously, is a complex multi-component process involving cues from extra-cellular growth factors and ovarian hormones [ 72, 94].
Uptake of ALA-ester destined for intra-cellular cleavage at the same time as ALA derived from extra-cellular cleavage, may have resulted in greater ALA availability for porphyrin biosynthesis than could have been achieved by ALA-ester uptake alone.
At the plasma membrane, PrPC could take up iron directly from the extra-cellular milieu and deliver to an endosomal compartment as suggested for copper [34].
miRNAs from the extra-cellular samples form a subset of those expressed in the intracellular samples.
Shear stress is sensed and transduced from the extra-cellular space to the intracellular skeleton.
In other words, signals coming from the extra-cellular matrix to the mammary epithelial cells are attenuated.
Integrins are the primary mediators of signals from the extra-cellular matrix that affect cellular gene expression or changes in morphology [ 48, 49].
Upon appropriate depolarization of the cell, a conformational change occurs in the sodium channel molecule such that an aqueous path opens to permit movement of Na+ from the extra-cellular phase into the cell under the existing electrochemical driving forces.
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