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In the budding yeast Saccharomyces cerevisiae, the subunits of any given protein complex are either mostly essential or mostly nonessential, suggesting that essentiality is a property of molecular machines rather than individual components.
Similarly, others have shown that essential genes are concentrated into specific complexes and that protein complexes are either mostly essential or mostly nonessential, suggesting that essentiality is a property of molecular machines rather than individual components (fig. 1 A) (Dezso et al. 2003; Hart et al. 2007; Semple et al. 2008; Wang et al. 2009).
pombe complexes are disproportionately mostly essential or mostly nonessential (fig. 4 A), confirming that modular essentiality is conserved across species.
E-Cadherin in epithelial adherens junctions, Dsg-2 in desmosomes, β4 integrin in hemidesmosomes, CD44s in cell-matrix interactions, and ICAM-1 are, mostly, essential for tissue integrity, architecture, and function in normal salivary gland parenchyma.
It has been demonstrated, using yeast co-expression networks, confirmed with knockout strain studies, that these network hubs are mostly essential genes [ 8, 9].
We found, as in previous studies, that complexes are mostly essential or mostly nonessential, but that it is not an all or nothing phenomenon.
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These regions are called "repeat deserts," which mostly have essential genes.
Nutrient reference values are set by Codex Alimentarius and regulatory bodies in many countries, mostly for essential nutrients with recommended daily intakes.
Taken together, data obtained from both mouse and human tissues suggest that hepatocytic differentiation is accompanied by a transition from an EpCAM-positive to an EpCAM-negative state of cells, which mostly recapitulates essential stages of embryonic hepatogenesis.
Within the Mediterranean basin, trade was mostly in essentials or things regarded as such.
Plasmids are extrachromosomal elements that carry mostly non-essential genes.
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