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For the genes that have functional annotations, GO term enrichment revealed that the genes are mostly enriched in organic acid metabolic process (supplementary table S3, Supplementary Material online) and very interestingly also "leaf development" on this scaffold.
Consistent with previous reports, the coregulated long-chained PS and PE species were mostly enriched in the plasma membrane fraction, while the PC species were mostly ER-enriched (van Meer et al., 2008).
Active histones H3K4me3, H3K9Ac, H3Ac and repressive histone H3K27me3 mostly enriched in euchromatin did not show noticeable differences in their protein levels between pES and ES cells, whereas heterochromatic repressive H3K9me3 levels were reduced in pES cells compared with ES cells (Fig. S1C).
In contrast, presynaptic proteins, Rab3, NRG1, synaptophysin, vGAT, vGlut1, were mostly enriched in the SV fraction but not in the PSD fractions (D' or D).
Similar to our observation in granule cells, Syp-GFP puncta are mostly enriched in Golgi cell axons in the granular layer, although some Syp-GFP is also present in distal dendritic branches.
Pathway analysis showed that significant differentially expressed genes (p<0.01) were mostly enriched in the glycolysis pathway, cell cycle checkpoint II pathway and plk3 pathway, which included 24, 10 and 10 genes, respectively (p<10−5).
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Taken together, in these consensus networks, the negatively correlated modules were mostly enriched for genes involved in neuronal and mitochondrial function, the positively correlated modules were mostly enriched for inflammatory pathway genes in the two cancers and for regulators of transcription and neurogenesis in DM1 and DM2 (Additional files 6, 7, 8 and 9 and Table 6).
Notably, these pathways are mostly enriched with up-regulated genes in cancer, suggesting a possible activation of these processes.
This class was mostly enriched by genes that participate in protein metabolism including protein modifications (67 genes to GO 0044267; p = 4.8 × 10-7) plus 32 genes that were likely involved in cellular metabolism (total of 99 genes to GO 0044237; p = 3.2 × 10-8).
For each patient, one area of primary tumor and one area of metastasis were selected after scanning all cores for tumor epithelium mostly enriched with tumor infiltrating leukocytes (TILs), in accordance with a previously described protocol [ 21].
Cluster ii includes 36 chemicals active in 7 to 65 assays, mostly enriched with GPCR (other) and ion channel assays, and includes five other assay enrichment categories.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com