Sentence examples for mostly elucidated from inspiring English sources

The evolutionary histories of these basins have been mostly elucidated based on geophysical and geological data (e.g., Kobayashi et al. 1995;Okino et al. 1999;Deschamps and Lallemand 2002).

Except for CPT-11, all four chemotherapeutic agents have been examined in many phase III trials in patients with advanced NSCLC and their roles have been mostly elucidated.

The existence of stage specific, differentially expressed transcripts in a number of species is consistent with their regulatory role which is however mostly not elucidated.

The last 60 years of research in the field of epigenetics was focused mostly on elucidating the molecular mechanisms and the enzymatic machinery responsible for epigenetic control of gene expression, as well as the distribution of various epigenetic marks in different cell types from healthy and diseased tissues and organisms.

All pterioidean species for which reproductive strategies have been elucidated (mostly members of the genera Pinctada and Pteria), are rhythmical protandrous hermaphrodites, with occasional instances of protogyny and simultaneous hermaphroditism, and mtDNA appears to be maternally inherited [ 128].

However, the more detailed molecular mechanism of vesicular BCRP trafficking regulated by the PI3K/Akt pathway mostly remains to be elucidated.

Modelling studies have mostly focused on elucidating the principles of community response to fragmentation and habitat loss at relatively large spatial and temporal scales relevant to metacommunity dynamics.

Beside a critical role in nicotine addiction, the role of nicotinic receptors in cognitive or emotional processes remains difficult to elucidate, mostly because of a lack of specificity of compounds and because they up or down regulate easily.

The pathophysiological mechanisms of drug-induced hepatotoxicity are still to be elucidated, but are mostly initiated by generation of hepatotoxic metabolites in the phase I of drug metabolism that often leads to the mitochondrial inhibition and accumulation of reactive oxygen species (ROS).

Indeed, neurophysiological studies have elucidated that several neuropathic mechanisms, mostly subclinical, act at different levels of the neuraxis and may contribute to the pathophysiology of primary BMS [3, 6].

However, which biochemical processes that lead to lipid accumulation of MR visible signals is still enigmatic, and the source and complete characteristics of the lipids found mostly in high grade brain tumors are still not elucidated [ 21, 22].