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Here, we find that ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct genomic loci, and regulate mostly distinct genes.
The cyan line and surrounding cyan-shaded region stand for the moment Open image in new window Fig. 4 Average assessment values and variance regions for controls and for patients before (Pre) and after treatment start (Post) for 16 variables: despite some overlaps, lines and regions of patients are mostly distinct from those of the controls.
The vGluT immunosignal in the lamina was mostly distinct from that seen with the OK371-Gal4 [55], representing vGluT promoter expression (Fig. 7A,B).
Based on the low similarities in faunal composition among sub-regions, the deep-sea census region appears to be mostly distinct from the continental shelf of the Gulf of Maine.
However, it has subsequently been suggested by several investigators that interspecies GBS transmission is not likely because genotyping data has demonstrated that human- and bovine-derived GBS strains represent mostly distinct populations [7], [8], [9], [10], [11], [12], [13].
In the non-transformed MCF10A cells the genes whose expression was significantly changed after TAIII treatment were mostly distinct from transcripts affected in cancer cell lines (Table S2), which could reflect the resistance of MCF10A to apoptosis induction by TAIII.
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Humpbacks around Madagascar, the huge island of the coast of East Africa, sing songs mostly quite distinct from those across the ocean, off the shores of West Australia.
Therefore, in contrast with our original predictions, it seems likely that movements offset by 90° are controlled mostly by distinct rather than overlapping populations of neurons.
Altogether our results demonstrate that MSL and NSL bind mostly to distinct sites in mESCs.
TEM of such cell populations allowed sporadic detection of perpendicularly sectioned NPCs that were juxtaposed to heterochromatic or nucleolar material but now mostly lacked distinct exclusion zones.
These siliceous lamellae mostly remain distinct (d ; Hexactinellida) or fuse completely by a biosintering process (e ; Demospongiae), creating a "solid" siliceous mantel that surrounds the axial filament (af ).
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