None of these cell types display features of melanoblasts (being mostly terminally differentiated cells, see figure s4g, h).
Therefore endocrine cell turnover in these circumstances may rely mostly on differentiated cell proliferation.
TET1 and TET2 are preferentially expressed in ESCs, while TET3 is mostly found in differentiated cells.
The luminal cells should be mostly represented by differentiated cells, and genes in these cells would be expected to be upregulated during HC11 differentiation.
In contrast to the majority of CA isoforms that are mostly present in differentiated cells of the normal tissues, CA IX expression is predominantly associated with a broad range of tumours derived from cells, which contain no or low level of CA IX (Potter and Harris, 2003).
Interestingly, Wcre-mediated gene switching did not result in accelerated tumor development in parous females when compared with the incidence in virgin females or the tumor-free survival in our models, indicating that Cre recombinase activity during gestation and lactation is mostly restricted to differentiated cells that do not contribute to mammary tumor formation.
Also, Schmid et al. [ 25] suggested that the intrarenal activation of cytotoxic T cells, which are mostly differentiated from CD8+ T cells, may be one of the pathomechanisms of interstitial nephritis, as they dominated in the interstitial lymphocytes.
pS6 was mostly absent from the differentiated cells in the retina but stained the CMZ intensely (Fig. 5A).
The H3K4me3/H3K27me3 bivalent promoter state that is prevalent in embryonic stem cells but mostly absent from terminally differentiated cells is such an example (Bernstein et al., 2006).
In the Mediterranean mussel, agranular hemocytes are cells able to divide as they show replication-dependent chromosomal damage [ 98] whereas the heterogeneous and abundant granulocytes can be regarded as differentiated cells, mostly phagocytic and able to release antimicrobial peptides [ 41].
