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One of the distinct features of the polymorphism observed by Meinhardt et al. (73) is that 2-fold symmetry is mostly conserved for all 11 amyloid fibril models (except fibril model 12) constructed from cryo-EM (not shown here).

In addition, we used treerex resulting in a detailed reconstruction of the rearrangement history and our analysis revealed that the evolution of gene orders in filamentous ascomycetes is mainly driven by transposition events and that gene orders are (mostly) conserved for close relatives.

These proteins are mostly conserved from yeast to metazoan.

Gp120 structures are composed of an inner and an outer domain; the inner domain varies substantially including the refolding of the bridging sheet, while the outer domain harbouring the CD4 binding site is mostly conserved except for the refolding of the CD4-binding loop [12], [13].

After performing PCA, a plot of the first two principal components revealed several interesting relationships between the metaclusters, and these relations between clusters were mostly conserved between a permissive and conservative strategy employed for functional associations.

However, sequence alignments show that the residues currently identified as being important for catalysis [ 72] are mostly conserved within the family.

Our analyses showed that the genes in the up-regulated and down-regulated gene clusters were mostly conserved during mouse and human organogenesis and are likely responsible for the similarities between mouse and human organogenesis.

For comparison, essential genes of B. subtilis are mostly conserved in the studied genomes (Additional file 1: Figure S1).

However, blood is simpler to obtain, particularly for serial sampling; and, genetic cis effects on gene expression are mostly conserved between adipose tissue and whole blood [36].

Secondary structure topologies are mostly conserved across the four binding proteins considered here.

For the most part, pairwise differences within the H-bond networks occur within non-secondary structure (primarily sidechain) H-bonds, meaning that the secondary structure H-bonds are mostly conserved.