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Moreover, this review does not discuss the issue of side effects and clinical efficacy of celecoxib, but focuses on its potential tissue structure-modifying, mostly chondroprotective, effects.
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However, if we consider chondroprotective effects, GlcN-HCl and GlcN-S were more effective than Glc and GlcA.
The primary objective of this study was to test the potential chondroprotective effects of intra-articular minocycline following osteochondral injury.
Its effectiveness is due to the many methods of actions it deploys, including lubrication, anti-inflammatory and chondroprotective effects.
As stated before, HA treatment has shown many beneficial effects in studies and experiments such as intraarticular lubrication, anti-inflammatory, analgesic and chondroprotective effects, among others [20].
In the hCol1 supplemented mice, chondroprotective effects were observed in injured knee joints, with dose-dependent increases in cartilage area, chondrocyte number and proteoglycan matrix at 3 and 12 weeks post-injury.
Administration of Salubrinal has chondroprotective effects in arthritic joints.
CBE therefore exhibits promising analgesic, anti-inflammatory, and chondroprotective effects.
The chondroprotective effects of another PE were reconfirmed in the monoiodoactate-induced OA model [ 8].
They have displayed chondroprotective effects in various animal models of arthritis.
However, there has to date been no comparison of the chondroprotective effects of GlcN derivatives.
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