Recently, several biological activities of fisetin have been identified including neuroprotective, anti-inflammatory and anticarcinogenic effects.
Our results suggest that the antioxidant activity of lycopene is an important mechanism through which lycopene exerts its anticarcinogenic effects.
Biomedical studies with animal models have demonstrated that cis-9, trans-11 conjugated linoleic acid (CLA), the predominant isomer found in milk fat from dairy cows, has anticarcinogenic effects.
These compounds are known to have antioxidant, antimutagenic and anticarcinogenic effects.
It was reported that the Rosa canina L. fruit, with its high ascorbic acid, phenolics and flavonoids contents, have antioxidant, antimutagenic and anticarcinogenic effects.
Garlic has a great pharmacological role, as it has been found that the sulfur-containing compounds of garlic have antimutagenic and anticarcinogenic effects (Mikaili, Maadirad, Moloudizargari, Aghajanshakeri, & Sarahroodi, 2013; Kimura et al., 2017).
Further, RA has anticarcinogenic effects in a murine, two-stage skin carcinogenesis model by inhibiting the inflammatory response and scavenging of reactive oxygen radicals [14].
The X-SCID rats established in this study provide not only a valuable in vivo model for evaluating drug treatment or gene therapy approaches, but also a system for assaying novel anticarcinogenic effects on transplanted malignancies.
Currently, the precise cellular and biochemical mechanism by which DIM exerts its anticarcinogenic effects remains to be fully elucidated but based on available literature, DIM interferes with various signal transduction pathways.
Although curcumin has long been used as a dietary spice, it has recently been shown to possess antibacterial, antiulcerogenic and anticarcinogenic effects on various experimental models [9], [19], [20], [34].
