For the development of new classes of antibiotics, NIAID-supported researchers and others are determining what specific biochemical pathways are most vulnerable to drug intervention in non-replicating, persisting microbes and whether treatment can be shortened when drugs are combined in innovative ways.
The sad thing is that they may be even more important for our most vulnerable students who may find their pathway to academics through athletics and the arts with quality coaches, amazing mentors, teamwork and appreciation of the value of delayed gratification.
Within the striatum, MSSNs that project to the external globus pallidus (indirect pathway) are the most vulnerable (Reiner et al., 1988; Albin et al., 1992).
Ban came to the negotiations in Doha in an attempt to "accelerate the process" of shifting the world to a clean-energy pathway, and helping the most vulnerable countries adapt to inevitable warming.
Consequently, these neural pathways are among the most vulnerable to long-term damage after developmental exposure to chlorpyrifos (Aldridge et al. 2005b; Dam et al. 1999; Slotkin et al. 2002, 2007; Slotkin and Seidler 2007).
"NHS organisations are working together to enact local heatwave plans, which include putting extra capacity into unscheduled care pathways, and proactively supporting the most vulnerable patients at home.
Darling-Hammond, Sean, Reneee v. Duncan: The Perilous Pendulum of National Politics and a Pathway to Protecting Our Nation's Most Vulnerable Youth" (2013).
The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway.
Considerably more information is needed on the pathways by which weather can affect health, on the subgroups most vulnerable to climate-sensitive health determinants and outcomes, and on the implications of climate change for public health policy and practice.
Furthermore, all calcareous species exhibited consistent pathways of degradation whereby the most recently formed chambers were the most vulnerable to degradation.
