Sentence examples for most vulnerable cell from inspiring English sources
But advocating for the full adoption of high-speed broadband in under-represented communities without questioning the quality of the Internet service we get, and leaving the most vulnerable cell phone users open to the predatory practices of the cell phone industry is less than adequate representation.
For modeling the most vulnerable cell type in HD, we used rat embryo derived striatal neurons with inducible mutant huntingtin expression [16].
With this objective in mind we report here the effects of concentration, exposure time and surfactant structure on the in vitro viability of mammalian cells that model the most vulnerable cell types that exist in the human cervicovaginal mucosa, namely, fully polarized columnar epithelial cells (MDCK and Caco-2), human cervical non-polarized epithelial cells (HeLa) and dendritic cells (FSDC).
It is known that neural progenitor cells and mature post-mitotic oligodendrocytes are the most vulnerable cell populations to various chemotherapeutic agents [73,74].
This hypothesis is supported, first, by studies showing that chronic hypoxia presumably causes WMLs and lacunar infarcts given that oligodendrocytes are the most vulnerable cell type under these conditions and that their degeneration contributes to the development of WMLs and lacunar infarcts [ 48, 82, 83, 101, 122, 152].
The finding that cPLA2 was mainly localized in neurons and oligodendrocytes is particularly interesting, because these 2 cell types not only play important roles in normal central nervous system (CNS) function but also are the most vulnerable cell types to injuries as compared to other CNS cell types such as astrocytes and microglia.
The primary effect of radiation is DNA damage and there is evidence that the most vulnerable cells are the endothelial cells.
In the present study, we explored whether expression of wild-type MAPT affects DA neurons, the most vulnerable cells in PD, by using a Drosophila animal model.
Due to this complex differentiation program, and due to their unique metabolism/physiology, oligodendrocytes count among the most vulnerable cells of the CNS.
A limitation of our study is the reliance on post-mortem tissue which represents end-stage disease and may exclude the most vulnerable cells which have already been lost; as such we await validation of our findings in model systems.
These findings suggest that different brain cells show variable efficiency in dealing with oxidative stress, with the observed susceptibilities conforming with the results of our study, which demonstrate that astrocytes are the most vulnerable brain cells to toxicity of WC-Co.
