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The reason is that most variants do not have any mutations in common (of the 105 different amino acid mutations, only 12 occur in more than one variant).
It should also be noted that at present most variants do not have data to support a quantitative assignment of variant certainty to any of the five categories given the heterogeneous nature of most diseases.
Genome wide association studies have been hugely successful in identifying disease risk variants, yet most variants do not lead to coding changes and how variants influence biological function is usually unknown.
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While most satRNA variants do not modify or attenuate CMV symptoms in most plant species, in tomato, two main phenotypes can be distinguished, those that attenuate CMV symptoms (A-satRNAs) and those that aggravate them to a systemic necrosis (N-satRNAs).
However, most of these variants do not appear to be functional.
Most genetic variants did not affect the primary endpoint.
In general, most of these chromosomal variants do not capture enough adaptive alleles to go beyond the early phases of establishment, or they are otherwise selectively neutral and lost by drift.
Most of the reported variants do not affect protein function in an obvious manner and indeed a large number lie in introns or intergenic regions [ 1], indicating that they may function through other regulatory mechanisms such as control of gene expression or alternative splicing.
This is most likely because these variants do not produce CMV CP, which is known to be a determinant of CMV systemic spread in plants [ 21, 22], and thus these infections were localized to the infiltrated regions of the treated leaves.
Most of the well-established particle swarm optimization (PSO) variants do not provide alternative learning strategies when particles fail to improve their fitness during the searching process.
Because truncating variants do not fit the known variant spectrum in most mitochondrial genes, their significance may be uncertain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com