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If these two proteins are very sequence similar, most variants between them are likely 'neutral' with respect to the EC number.
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Guided by the stable rDNA RFLPs, we cloned seven v-rDNAs; copy number analyses suggest that most variants contain between 8 15 copies; we identified variant-specific SNPs in the transcribed sequence and variant-specific PCR revealed variable expression of these v-rDNAs in different tissues; and v-rDNA expression profiles are conserved within and among mouse strains.
Average coverage of the 23 samples was at least 490X in the reactions: Most variants were concordant between two different MPS platforms and with non-coding region data generated by Sanger sequencing.
Most variants are predicted above 95% accuracy.
One hundred sixty-seven most variant CpG sites.
For primates, the Ka/Ks was computed for the most similar orthologous splicing variants between human and primate protein-coding sequence (Matsuya et al. 2008; Georgi et al. 2013).
For most missense variants, however, the distinction between phenotypically active and neutral alleles is not straightforward, especially as population genetic theory and empirical observations suggest that even functional missense variants will mostly have small effect sizes [ 86].
There are 14 different genomic variants listed in the region proximal to BP2 and most of these variants are SDs, but there are two inversion variants between BP1 and BP2, and one inversion variant between BP2 and BP3 was previously reported [ 74].
The most common genotypes were blaCTX-M-1 and blaCTX-M-14, but there was a large variation between blaCTX-M variants between countries (Table 2).
As expected, most genetic variants were found to increase the risk of cancer, but a few protective variants were also identified.
The most common variant is fusion between the 5′-untranslated 5′-untranslatedS2 and the 3′ region of ERG.
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