An expert criterion was used as a weighting factor to enhance the most significant variables defining the quality of a dive experience, then the data were analyzed from a zonal classification approach, followed by a non-metric MDS analysis conducted to corroborate the emerged patterns and a PERMANOVA analysis to identify significant differences between zones and seasons.
For each cancer type, we selected the most variable introns, defined as having a standard deviation of changes in intron retention for tumor-normal pairs across all patient samples exceeding 0.1 (AML: 852 introns, breast cancer: 621 introns, colon cancer: 740 introns).
(7 9) for different variables defined.
Based on the results of our analyses, the most important variables defining organizational models were resource-related, namely number of providers and types of providers represented, presence of secretaries and specific work environment.
†The "extensive exposure" variable defined a priori.
The most heterogeneously defined variable was "Survival Status" (the Utstein recommendation is outcome at Day 30 after injury [ 11]), and 11 (46%) centres used different definitions (Table 3): six used outcome at end of acute care stay, three used the in-hospital 30-day outcome, and two used the outcome at the end of total somatic stay (including rehabilitation).
The survival free of major complications which represents besides mortality the most crucial variable defining neonatal outcome, significantly increased.
Most clinicopathologic variables were defined as in previous studies (Anderson et al, 2001, 2002) and are detailed in Table 1.
Most variables are self explanatory.
Peak-regions with significant changes in H3K9ac were determined by high-dimensional T-test analysis, defining the most variable candidate regulatory regions.
