Sentence examples for most variable residues from inspiring English sources

The most variable residues in the ATP pocket are targeted to design specificity into inhibitors in our various kinase projects.

As it can be deduced from figure 4, those residues belonging to the Exposed Noncontact groups from COX II and COX III are among the most variable residues (P values 0.003 and 0.045, respectively).

OsALDH families 6 and 11 displayed the most conserved catalytic cleft (Figure S4B, Figure S7B), while OsALDH family 2 showed the most variable residue composition in its catalytic cleft (Figure S1B).

An analysis of structural residue conservation revealed similar residue patterns in all OsALDHs, with the most variable surface residues (depicted in blue) located on the periphery and the conserved residues (depicted in purple) located in the core of the protein structures (Figure 4B, Figures S1B, S2B, S3B, S4B, S5B, S6B, S7B, S8B, S9B, S10B, S11B, S12B, and S13B).

The 1A protein of serotype O was most conserved, with only four variable residues and hypervariable regions that were not common for 1A (not shown).

Moreover, Figure 5 demonstrates that the least conserved residues (or most variable) occur on the exposed surface of the planar β-sheet where 5S RNA binds to the L5 proteins.

Evidence indicates that the RXLR and associated dEER (Asp-Glu-Glu-Arg; the leading Asp residue is most variable) motifs are targeting elements that deliver the protein effector inside the host cell [15], [16], [17], [18].

Although positions 3 and 4 are variable, there is a strong bias for negatively charged residues at position 3 and the uncharged polar residues serine and asparagine at position 4. Position 7 of the eh1-like motifs is most variable, with glycine, alanine and serine residues often present.

The N-terminal portion of the protein from amino acid residues 1-166 of the multiple sequence alignment was the most variable portion of the protein, and corresponds within approximately 5 residues to the enzymatically active domain (EAD) determined structurally and experimentally [ 22] for the endolysin from Listeria phage 2389 (NC_003291).

The evolutionarily most important residues interact with the most conserved base-pairs within the response element while residues of least importance interact with the most variable base-pairs.

Loop 2 is one of the most variable regions among the DU family of USPs and is six residues shorter in USP11 compared to USP15 and USP4.