However, despite all the criticism it has drawn, TAM has become one of the most valid models in the literature evaluating the acceptance of technology at an individual level, and is one of the most widely accepted behavioral models in the field of information technologies (Legris, Ingham, & Collerette, 2003, p. 202; McCoy, Galetta, & King, 2007, p. 81; Turan & Çolakoğlu, 2008, p. 112).
In vivo studies are considered to provide the most valid models of human critical illness because they utilise integrative mammalian physiology.
Instrumented dogs or rabbits are the most valid models, but cannot be used for screening large number of NCEs, both for ethical and financial reasons.
Ultimately, linking the neurophysiological and cellular/biochemical actions that contribute to the expression of a defined MDD-like syndrome will dramatically extend the translational value of the most valid animal models of MDD.
Thus, the mdx mouse, lacking a functional dystrophin gene, represents the most valid pre-clinical model, considering also that the double mutant mice do not resemble the genetic background of DMD patients and are therefore less appropriate to predict therapeutic effects (Willmann et al., 2009).
However, because our repeated outcome was most accurately classified as a count variable following a binomial distribution, we trusted the estimates from the generalized estimating equation model and the corresponding multi-level model to be the most valid estimates.
Because the mixed model was a combination of models with a higher coefficient of determination, we believed the mixed model to be the most valid for this study.
Hence, combined efforts in the industry and academia should be paid to define the animal models and assays that are the most valid for nonclinical immunotoxicity evaluation and to design more sensitive predictive models.
The models for gt2_ADLs provide the most valid index for predicting patients that will experience functional decline.
In essence, predictive modeling relies on sourcing the most valid and reliable data available, and then recalculating those data over time.
