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Although the randomized controlled trial may be considered the most valid design, well-designed observational studies often yield similar results.
Creating the most valid design to prospectively examine the effectiveness and costs of competing pharmacotherapies requires a dialectic of opposing research paradigms.
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The most valid adaptive designs are those in which the opportunity to make adaptations is based on prespecified decision rules that are fully documented in the protocol (Item 21b).
Though an RCT would provide the most valid data on efficacy, the prospective cohort design seemed substantially superior to uncontrolled case series, which remain the predominant study design in the surgical literature.
The crossover design is considered the most valid.
Hence, combined efforts in the industry and academia should be paid to define the animal models and assays that are the most valid for nonclinical immunotoxicity evaluation and to design more sensitive predictive models.
The base case was determined from the 3-year post-diagnosis HRQOL data of men initially managed with active surveillance; in the absence of a randomised design, this group was deemed the most valid comparator.
Most valid data came from large multicentre trials that have been designed and sponsored by the manufacturers of the modern 5-HT3 receptor antagonists.
While the whole story of the "X Files" plot lines may never be revealed, one "out there" truth is that, by design or accident, the series puts those with even the most valid conspiracy theories, or even confirmed accusations, about government misdeeds into the same category as those who find extraterrestrials making cryptic designs in their cornfields.
That is the most valid letter any reader could write.
"That's probably the most valid point," he says.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com